✦ LIBER ✦

Bcl-xL mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells

✍ Scribed by Gisela G. Chiang; William P. Sisk

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 238 KB
Volume: 91
Category: Article
ISSN: 0006-3592
DOI: 10.1002/bit.20551

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Mcl-1 overexpression leads to higher via

Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells

✍ Brian S. Majors; Michael J. Betenbaugh; Nels E. Pederson; Gisela G. Chiang 📂 Article 📅 2009 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 462 KB 👁 2 views

Overexpression of bcl-2 inhibits sodium

Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production

✍ No Soo Kim; Gyun Min Lee 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB 👁 2 views

Impact of gene vector design on the cont

Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells

✍ Sarah L. Davies; Peter M. O'Callaghan; Jane McLeod; Leon P. Pybus; Yun Hee Sung; 📂 Article 📅 2011 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 468 KB 👁 2 views

## Abstract In this study, we systematically compare two vector design strategies for recombinant monoclonal antibody (Mab) synthesis by Chinese hamster ovary (CHO) cells; a dual open reading frame (ORF) expression vector utilizing separate cytomegalovirus (CMV) promoters to drive heavy chain (HC)

Effect of Bcl-xL overexpression on apopt

Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition

✍ Yeon-Gu Kim; Jee Yon Kim; Chaya Mohan; Gyun Min Lee 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 475 KB 👁 2 views

## Abstract Upon nutrient deprivation during culture, recombinant Chinese hamster ovary (rCHO) cells are subjected to two types of programmed cell death (PCD), apoptosis and autophagy. To investigate the effect of Bcl‐x~L~ overexpression on apoptosis and autophagy in rCHO cells, an erythropoietin (

Mechanisms of unintended amino acid sequ

Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells

✍ Donglin Guo; Albert Gao; David A. Michels; Lauren Feeney; Marian Eng; Betty Chan 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 428 KB 👁 2 views

## Abstract An amino acid sequence variant is defined as an unintended amino acid sequence change and contributes to product heterogeneity. Recombinant monoclonal antibodies (MAbs) are primarily expressed from Chinese Hamster Ovary (CHO) cells using stably transfected production cell lines. Selecti

Improved production of recombinant human

Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression

✍ Tomoshi Ohya; Tetsuji Hayashi; Eriko Kiyama; Hiroko Nishii; Hideo Miki; Kaoru Ko 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 260 KB 👁 2 views

## Abstract To improve the production of recombinant human antithrombin III (AT‐III) in Chinese hamster ovary (CHO) cells, the genes encoding transcription factors, ATF4 (activating transcription factor 4) and XBP‐1s (the spliced form of X‐box binding protein 1), which were involved in the mammalia