Abnormal cell adhesion is an important contributing factor in invasion and metastasis. Here, we show that morphologically 'normal' cell-cell and cell-substratum adhesion can be restored to a poorly differentiated carcinoma cell line by activation of protein kinase C (PKC). This cell line, VACO 10MS,
Correlation Between Cell-Cell Contact Formation and Activation of Protein Kinase C in a Human Squamous Cell Carcinoma Cell Line.
β Scribed by Nagao, Seiji; Kitajima, Yasuo; Nagata, Koh-Ichi; Inoue, Shunichiro; Yaoita, Hideo; Nozawa, Yoshinori
- Book ID
- 110681928
- Publisher
- Nature Publishing Group
- Year
- 1989
- Tongue
- English
- Weight
- 691 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0022-202X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Loss of heterozygosity (LOH ) of mouse chromosome 7 has been consistently demonstrated in chemically induced murine squamous cell carcinomas (SCCs). The region of this chromosome presenting LOH in the mouse tumors is syntenic to human chromosome segments I I p I 5 and I I q. To determine whethe
## Abstract Protein kinase C (PKC) represents a large family of phosphatidylserine (PS)βdependent serine/threonine protein kinases. At least five PKC isoforms (Ξ±, Ξ΄, Ξ΅, Ξ·, and ΞΆ) are expressed in epidermal keratinocytes. PKC isoforms are differentially expressed in proliferative (basal layer) and n
Background. To detect epigenetic changes in head and neck squamous cell carcinoma (HNSCC) and between metastatic and nonmetastatic tumors, we performed a systematic phosphorylation screening on different protein kinases. Methods. The phosphorylation levels of the serine-threonine kinase Akt, of mit