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Human chromosome II inhibits tumorigenicity of a murine squamous cell carcinoma cell line

✍ Scribed by Jean C. Zenklusen; Mibuo Oshimura; J. Carl Barrett; Claudio J. Conti

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 538 KB
Volume: 13
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870130108

No coin nor oath required. For personal study only.

✦ Synopsis

Loss of heterozygosity (LOH

) of mouse chromosome 7 has been consistently demonstrated in chemically induced murine squamous cell carcinomas (SCCs). The region of this chromosome presenting LOH in the mouse tumors is syntenic to human chromosome segments I I p I 5 and I I q. To determine whether the introduction of human chromosome (Hchr) I I can suppress the growth of murine SCC, we injected four clones of a chemically induced murine SCC cell line bearing an Hchr I I into athymic BALB/c nude mice. All microcell hybrid clones with Hchr I I (CH721Hchr I I) had latency periods twice as long as those of the parental CH72 cells and control hybrids containing a Hchr 12. Tumor-derived cells from CH721Hchr I I hybrids had lost centromeric and telomeric sequences from Hchr I I. All repressed cell lines grew significantly m e slowly in vitro than did the controls. These results suggest that Hchr I I contains a tumor-suppressor gene capable of inhibiting tumorigenicity in chemically induced SCC, confirming common pathways in the development of human neoplasias and the murine model. Genes Chrornosorn Cancer 13:47-53 (1995).

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