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Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma

✍ Scribed by Lara Tosi; Eliana Rinaldi; Francesco Carinci; Antonio Farina; Antonio Pastore; Stefano Pelucchi; Lazzaro Cassano; Rita Evangelisti; Paolo Carinci; Stefano Volinia

Book ID
102847510
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
893 KB
Volume
27
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. To detect epigenetic changes in head and neck squamous cell carcinoma (HNSCC) and between metastatic and nonmetastatic tumors, we performed a systematic phosphorylation screening on different protein kinases.

Methods. The phosphorylation levels of the serine-threonine kinase Akt, of mitogen-activated protein kinase (MAPK), and of protein kinase C (PKC) beta and epsilon were measured in a series of 94 biopsy specimens, corresponding to 47 HNSCCs and paired controls taken from clinically uninvolved tissue of the same patients.

Results. Akt and MAPK were significantly underphosphorylated (two-sided p < .004) in tumors, whereas PKCs showed no differences from control samples. Second, although in control tissue there was a significant correlation between phosphorylation levels of Akt, MAPK, and PKC (all two-sided p < .05), many correlated activations were lost in tumors and even more in lymph node -positive tumors. Finally, p44 MAPK and Akt pThr308 were phosphorylated in a coordinated fashion only in lymph node -positive tumors (two-sided p < .01).

Conclusions. This novel evidence documents important changes in the phosphorylation program during cancer progression of HNSCC.

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