𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Correlation between augmentative effects of leucovorin on 5-fluorouracil and thymidylate synthase inhibition

✍ Scribed by Yasuhide Yamada; Yuh Sakata; Kenichi Tsushima; Taro Satoh

Book ID
105594566
Publisher
Springer
Year
1997
Tongue
English
Weight
406 KB
Volume
2
Category
Article
ISSN
1341-9625

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Leucovorin enhancement of the effects of
Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase
✍ Richard G. Moran πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 536 KB

Exposure of tumor cells to reduced folates before or with the fluoropyrimidines, 5-fluorouracil or 5-fluoro-2'deoxyuridine, results in a substantial increase in the activity of these drugs. Available evidence suggests that the mechanism of this synergism is a kinetic stabilization of complex formed

Schedule dependent inhibition of thymidy
Schedule dependent inhibition of thymidylate synthase and tumor growth by 5-fluorouracil in yoshida sarcoma bearing rats
✍ Toshimasa Tsujinaka Md; Yoshihiro Kido; Hitoshi Shiozaki; Takesada Mori; Constan πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 431 KB

## Abstract Schedule dependent inhibition of thymidylate synthase (TS) and tumor growth by 5‐fluorouracil (FUra) was examined in Yoshida sarcoma (YS) bearing Donryu rats. After implantation of YS cells (1 Γ— 10^4^), FUra (20 mg/kg/day) was continuously (group C) or daily bolus injection (group B) ad