✦ LIBER ✦

Schedule-dependent inhibition of thymidylate synthase by 5-fluorouracil in gastric cancer

✍ Scribed by Toshimasa Tsujinaka; Yoshihiro Kido; Hitoshi Shiozaki; Shohei Iijima; Taro Homma; Masamori Sakaue; Takesada Mori

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 482 KB
Volume: 70
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19921215)70:12<2761::aid-cncr2820701206>3.0.co;2-f

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Schedule dependent inhibition of thymidy

Schedule dependent inhibition of thymidylate synthase and tumor growth by 5-fluorouracil in yoshida sarcoma bearing rats

✍ Toshimasa Tsujinaka Md; Yoshihiro Kido; Hitoshi Shiozaki; Takesada Mori; Constan 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 431 KB

## Abstract Schedule dependent inhibition of thymidylate synthase (TS) and tumor growth by 5‐fluorouracil (FUra) was examined in Yoshida sarcoma (YS) bearing Donryu rats. After implantation of YS cells (1 × 10^4^), FUra (20 mg/kg/day) was continuously (group C) or daily bolus injection (group B) ad

The prognostic significance of thymidyla

The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil

✍ Søren Astrup Jensen; Ben Vainer; Jens Benn Sørensen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 350 KB

## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30

Dependence of the thymidylate synthase i

Dependence of the thymidylate synthase inhibition rate on the interval after the last administration of tegafur in sigmoid colon cancer patients

✍ Dr. Mutsumi Nozue; Naoto Koike; Tohru Kawamoto; Kisako Toko; Takashi Sindou; Kaz 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB

The thymidylate synthase (TS) inhibition rate was measured after tegafur (FT) administration (1.5 g/day, at least 10 days) in 7 sigmoid colon cancer patients. The TS inhibition rate decreased as the interval between the time of the last administration and the time of the tumor resection increased lo

Single nucleotide polymorphism in the 5′

Single nucleotide polymorphism in the 5′ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients

✍ Eugenio Marcuello; Albert Altés; Elisabeth del Rio; Angeles César; Anna Menoyo; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 84 KB 👁 1 views

## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has

Schedule-dependent reversion of acquired

Schedule-dependent reversion of acquired cisplatin resistance by 5-fluorouracil in a newly established cisplatin-resistant HST-1 human squamous carcinoma cell line

✍ Taito Esaki; Shuji Nakano; Naoko Masumoto; Hiromitsu Fujishima; Yoshiyuki Niho 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 684 KB

Synergistic effects of docetaxel and S-1

Synergistic effects of docetaxel and S-1 by modulating the expression of metabolic enzymes of 5-fluorouracil in human gastric cancer cell lines

✍ Yoshiyuki Wada; Kazuhiro Yoshida; Takahisa Suzuki; Hirozumi Mizuiri; Kazuo Konis 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 412 KB 👁 1 views

## Abstract We have recently demonstrated in a Phase I/II study that combination chemotherapy with docetaxel (TXT) and S‐1 is active against metastatic gastric carcinomas. To elucidate the mechanisms underlying the synergistic effects of these drugs, both the growth inhibitory effects and the expre