✦ LIBER ✦
Dependence of the thymidylate synthase inhibition rate on the interval after the last administration of tegafur in sigmoid colon cancer patients
✍ Scribed by Dr. Mutsumi Nozue; Naoto Koike; Tohru Kawamoto; Kisako Toko; Takashi Sindou; Kazuo Orii; Tadashi Kondou; Yumi Mun; Manabu Nithou; Takeshi Todoroki; Katashi Fukao
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 368 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
✦ Synopsis
The thymidylate synthase (TS) inhibition rate was measured after tegafur (FT) administration (1.5 g/day, at least 10 days) in 7 sigmoid colon cancer patients. The TS inhibition rate decreased as the interval between the time of the last administration and the time of the tumor resection increased longer. This study provides basic data for considering methods of drug administration and assessment of modification, for example, by leucovorin.