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Copper(II) interaction and complexation with 1-[2(S)-3-mercapto-3-methylpropionyl]-L-proline (captopril)

✍ Scribed by Panayot R. Bontchev; Georgi Gochev; Bissera Evtimova; Hussein Kadum; Chudomir Nachev


Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
734 KB
Volume
46
Category
Article
ISSN
0162-0134

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EPR spectroscopy was used to elucidate the nature of the interaction between copper and the antihypertensive agent 1-[2(S)-3-mercapto-ZmethylpropionyI]-~-proline (Captopril) in both solid and aqueous solutions. The EPR spectra indicate that binding to copper(I1) occurs via the ligand oxygens rather

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## Abstract The dinuclear copper(II) complexes {[Cu~2~(1,3‐tpbd)(H~2~O)(OAc)~2~](ClO~4~)~2~}~0.23~{[Cu~2~(1,3‐tpbd)(H~2~O)~2~(OAc)](ClO~4~)~3~}~0.77~Β·0.77H~2~O (1), [Cu~2~(1,3‐tpbd)(H~2~O)~2~(OAc)~2~](ClO~4~)~2~Β·2H~2~O (2), and the tetranuclear copper(II) complex [Cu~4~(1,3‐tpbd)~2~(H~2~O)~2~(SO~4~