Electron paramagnetic resonance study of the complex formed between copper and 1-[2(S)-3-mercapto-2-methylpropionyl]-L-proline (Captopril) in solid and aqueous solution
✍ Scribed by Jeffrey C. Evans; Caroline R. Morris; Sian B. Rees; Christopher C. Rowlands; David R. Williams
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 324 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0749-1581
No coin nor oath required. For personal study only.
✦ Synopsis
EPR spectroscopy was used to elucidate the nature of the interaction between copper and the antihypertensive agent 1-[2(S)-3-mercapto-ZmethylpropionyI]-~-proline (Captopril) in both solid and aqueous solutions. The EPR spectra indicate that binding to copper(I1) occurs via the ligand oxygens rather than the thiol moieties, and that the EPR-detectable copper is greatly reduced on complexation. The EPR parameters for the solid copper(I1) complexes are in the range g,, = 2.374-2.386, g, = 2.076-2.086 and A? = 13.5 mT, and the parameters for the aqueous solutions are g,,o = 2.