Copper(I)-Catalyzed Enantioselective Substitution of Allyl Chlorides with Diorganozinc Compounds

✍ Scribed by Frank Dübner; Paul Knochel

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 89 KB
• Volume: 38
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/(sici)1521-3773(19990201)38:3<379::aid-anie379>3.0.co;2-y

✦ Synopsis

Ferrocenylamines are excellent catalysts for the enantioselective substitution of unsymmetrical allyl chlorides with dialkylzinc compounds in the presence of a copper(I) salt. For example, in the reaction shown in Equation (1), the product is formed with 87 % ee and a S 2':S 2 ratio of 97:3.