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Enantioselective Copper-Catalyzed Allylic Substitution Reaction with Aminohydroxyphosphine Ligand

✍ Scribed by Naohiko Yoshikai; Kotaro Miura; Eiichi Nakamura

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
440 KB
Volume
351
Category
Article
ISSN
1615-4150

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Ferrocenylamines are excellent catalysts for the enantioselective substitution of unsymmetrical allyl chlorides with dialkylzinc compounds in the presence of a copper(I) salt. For example, in the reaction shown in Equation (1), the product is formed with 87 % ee and a S 2':S 2 ratio of 97:3.