## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Copper(I)-Catalyzed Chlorine Atom Transfer Radical Cyclization Reactions of Unsaturated α-Chloro β-Keto Esters
✍ Scribed by Yang, Dan; Yan, Yi-Long; Zheng, Bao-Fu; Gao, Qiang; Zhu, Nian-Yong
- Book ID
- 118014365
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 222 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1523-7060
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## Abstract 5-Acetyl-4,5-dihydro-1-phenylpyrazolo[3,4-d]pyrimidin-4-one was prepared and subjected to various chemical transformations to give novel 5-heterocyclic pyrazolopyrimidinone derivatives of expected important biological activity. Then, the latter compounds were used to obtain β-keto ester
Treatment of cycloalkanones, each bearing b-iodo a,b-unsaturated ester or nitrile side chains, with tributyltin hydride and AIBN effected a 1,5-hydrogen atom transfer/radical cyclization sequence to afford the fused-or spiro-cyclic ketones.