1,5-Hydrogen atom transfer/radical cyclization of cycloalkanones bearing a β-iodo α,β-unsaturated ester or nitrile side chain

✍ Scribed by Chin-Kang Sha; Chu-Wei Hsu; Yu-Ting Chen; Su-Ya Cheng

• Book ID: 104211318
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 63 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01771-8

✦ Synopsis

Treatment of cycloalkanones, each bearing b-iodo a,b-unsaturated ester or nitrile side chains, with tributyltin hydride and AIBN effected a 1,5-hydrogen atom transfer/radical cyclization sequence to afford the fused-or spiro-cyclic ketones.