Copper-Catalyzed Reductive Cross-Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides
โ Scribed by Liu, Jing-Hui; Yang, Chu-Ting; Lu, Xiao-Yu; Zhang, Zhen-Qi; Xu, Ling; Cui, Mian; Lu, Xi; Xiao, Bin; Fu, Yao; Liu, Lei
- Book ID
- 126603154
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 390 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0947-6539
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๐ SIMILAR VOLUMES
Styrenes were alkylated with alkyl tosylates, sulfates and bromides in the presence of a zirconocene catalyst and "BuMgC1 in THF. By the use of this reaction, primary and secondary alkyl groups can be introduced regioselectively at the benzylic carbon of styrenes to give a-substituted ethylbenzenes.
Treatment of secondary or tertiary alkyl bromides with alkyl Grignard reagents in the presence of catalytic amounts of silver bromide and potassium fluoride in CH 2 Cl 2 afforded the corresponding cross-coupling products in reasonable yields. Moreover, silver showed catalytic activity for the cross-