Copper-Catalyzed Enantioselective 1,4-Addition to α,β-Unsaturated Aldehydes
✍ Scribed by Palais, Laëtitia; Babel, Lucille; Quintard, Adrien; Belot, Sébastien; Alexakis, Alexandre
- Book ID
- 120236744
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 274 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1523-7060
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The enantioselective copper-catalyzed 1,4-addition of Grignard reagents to a$-unsaturated carbonyl compounds was studied with the following Cu' compounds as catalyst precursor and 1,2 : 5,6-di-0 -isopropylidene-3thio-a -o-glucofuranose (Hsiig) as chiral ligand: CuI, iodo[bis(dibutylsulfide)]copper(I
The first examples of enantioselective addition of anthrones to a,b-unsaturated aldehydes are disclosed. The reaction was performed at À40 °C achieving high yields and enantioselectivities.