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Copper-Catalyzed Amidation of sp 3 C−H Bonds Adjacent to a Nitrogen Atom

✍ Scribed by Zhang, Yongming; Fu, Hua; Jiang, Yuyang; Zhao, Yufen


Book ID
120932344
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
73 KB
Volume
9
Category
Article
ISSN
1523-7060

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Copper-catalyzed trifluoromethylation via oxidative sp 3 C-H activation at the a-position of nitrogen in tetrahydroisoquinoline derivatives using DDQ and Ruppert-Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15-9