Copper-catalyzed oxidative trifluoromethylation of benzylic sp3 C–H bond adjacent to nitrogen in amines

✍ Scribed by Hiromasa Mitsudera; Chao-Jun Li

• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 349 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2011.02.038

✦ Synopsis

Copper-catalyzed trifluoromethylation via oxidative sp 3 C-H activation at the a-position of nitrogen in tetrahydroisoquinoline derivatives using DDQ and Ruppert-Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15-90% yields under mild conditions.