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Direct sp3 C—H Bond Activation Adjacent to Nitrogen in Heterocycles

✍ Scribed by Kevin R. Campos

Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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Copper-catalyzed oxidative trifluorometh
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✍ Hiromasa Mitsudera; Chao-Jun Li 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 349 KB

Copper-catalyzed trifluoromethylation via oxidative sp 3 C-H activation at the a-position of nitrogen in tetrahydroisoquinoline derivatives using DDQ and Ruppert-Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15-9