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Copper-Catalyzed Aerobic Oxidative Amination of sp 3 C–H Bonds: Efficient Synthesis of 2-Hetarylquinazolin-4(3 H )-ones

✍ Scribed by Li, Qiang; Huang, Yao; Chen, Tieqiao; Zhou, Yongbo; Xu, Qing; Yin, Shuang-Feng; Han, Li-Biao


Book ID
127006358
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
708 KB
Volume
16
Category
Article
ISSN
1523-7060

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Copper-catalyzed trifluoromethylation via oxidative sp 3 C-H activation at the a-position of nitrogen in tetrahydroisoquinoline derivatives using DDQ and Ruppert-Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15-9