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Coordination of the Nuclear and Cytoplasmic Activities of p53 in Response to DNA Damage

✍ Scribed by Pu, Tian; Zhang, Xiao-Peng; Liu, Feng; Wang, Wei

Book ID
119207470
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
629 KB
Volume
99
Category
Article
ISSN
0006-3495

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## Abstract The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other pro‐survival pathways. Howe