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Conversion of amino acids and dipeptides into their phosphonic analogs : Aminoalkylphosphonic acids and peptides II

✍ Scribed by George Ösapay; Ildikó Szilagyi; Jenö Seres

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
478 KB
Volume
43
Category
Article
ISSN
0040-4020

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✦ Synopsis

Acylamino carboxylic acids were degradated by the Hunsdiecker-reaction; the bromo-derivatives were reacted with NaPO(OQH5)z. Aminophosphonic acids were obtained by acidic hydrolysis, and half-blocked derivatives by the selective removal of masking substituents. Two phosphonopeptides [e.g. Alafosfalin (4i)] were also prepared by this route.

📜 SIMILAR VOLUMES

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