Convergent synthesis of oligomers of triazole-linked DNA analogue (TLDNA) in solution phase

✍ Scribed by Tomoko Fujino; Naomi Yamazaki; Hiroyuki Isobe

• Book ID: 104096571
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 283 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.04.101

✦ Synopsis

A convergent route for the solution-phase synthesis of oligomeric triazole-linked analogues of DNA ( TL DNA) has been developed. A one-pot procedure for desilylation of masked acetylene and the ensuing copper-catalyzed Huisgen coupling reaction between oligomers allowed the solution-phase synthesis of 7-mer and 8-mer TL DNA in good yield.