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Convenient synthesis of D-threo-[dichloroacetyl 1–14C] chloramphenicol

✍ Scribed by C. V. Sontakke; S. P. Patil; V. K. P. Unny; N. Sivaprasad

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
123 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A convenient synthesis of chloramphenicol labelled with carbon‐14 in the dichloroacetyl group at the 1 position is described. It was prepared as part of a 4‐step sequence from [1**‐^14^C] glycine and the product was purified by preparative HPLC. A radiochemical yield of 47% was obtained based on [1‐**^14^C] glycine and the product had a specific activity of 0.47 mCi/mmol. The procedure can be employed for the synthesis of high specific activity [^14^C] chloramphenicol, labelled at 1, 2 or both the positions of dichloroacetyl group. Copyright © 2005 John Wiley & Sons, Ltd.

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