## Abstract via acid‐catalyzed acylation of 2‐amino‐tetrahydrochromene‐3‐carboxylates (I)
Convenient selective synthesis of 5,7,8,9-tetrahydro-4H,6H-chromeno[2,3-d][1,3]oxazin-4-ones
✍ Scribed by Yu. M. Litvinov; A. M. Shestopalov
- Book ID
- 106521487
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 232 KB
- Volume
- 58
- Category
- Article
- ISSN
- 1573-9171
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📜 SIMILAR VOLUMES
The title compound, C 23 H 25 BrO 3 , was synthesized by the reaction of p-bromobenzaldehyde with dimedone and HClO 4 / SiO 2 in EtOH. In the molecule, the dihydropyran ring adopts a boat conformation and the two cyclohexene rings are in a trans conformation.
The asymmetric unit of the title compound, C 19 H 16 FN 5 O 4 , contains two independent molecules. The dihedral angles between the main planes and the fluorophenyl rings in the two molecules are 83.24 (5) and 71.76 (4) . Weakstacking interactions may be effective in the stabilization of the crystal
## Abstract Reaction of 5‐amino‐3‐methyl‐1‐phenylpyrazole (1a) and 5‐amino‐3‐(4‐chlorophenyl)‐1__H__‐pyrazole (1b) with dimedone (2) and __p__‐susbstituted benzaldehydes 3 in ethanol, afforded in all cases tricyclic linear 4‐aryl‐7,7‐dimethyl‐4,7,8,9‐tetrahydro‐6__H__‐pyrazolo[3,4‐__b__]quinolin‐5‐