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Convenient methods for the preparation of [5-14C]-4-ipomeanol and [3H(G)]-4-ipomeanol of high specific radioactivity

✍ Scribed by Michael R. Boyd; John S. Dutcher

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
226 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Procedures are described for the preparation of radiolabeled 4‐ipomeanol [1‐(3‐furyl)‐4‐hydroxypentanone], a highly selective pulmonary alkylating agent, of sufficiently high specific radioactivity for biochemical and autoradiographic studies. The ^14^C‐labeled material is prepared from the reaction of ethyl 3‐fur‐oylacetate with [3‐^14^C]‐propylene oxide; the tritiated product is obtained by catalytic tritiation using T~2~O or tritium gas as the source of the radiolabel.

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