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Convenient method for synthesis of thiazolo[3,2-a]pyrimidine derivatives in a one-pot procedure

✍ Scribed by Sukhdeep Singh; Andreas Schober; Michael Gebinoga; G. Alexander Groß

Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
458 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient one-pot method to synthesize thiazolo[3,2-a]pyrimidine derivatives has been developed. The method involves the temperature controlled functionalization-annulation of 5-ethoxycarbonyl-6methyl-4-aryl-3,4-dihydro-2(1H)-pyrimidin-2-thione (DHPM) derivatives with in-situ generated bromo-ketones received by reaction of different a-H carbonyl compounds with bromine.

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ChemInform Abstract: Convenient Method f
ChemInform Abstract: Convenient Method for Synthesis of Thiazolo[3,2-a]pyrimidine Derivatives in a One-Pot Procedure.
✍ Sukhdeep Singh; Andreas Schober; Michael Gebinoga; G. Alexander Gross 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

## Abstract Careful α‐bromination of ketones with elemental bromine and direct addition of pyrimidine‐2‐thiones and triethylamine renders possible a direct two‐step one‐pot synthesis of the title compounds.

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✍ Xiaofang Li; Aiting Zheng; Bin Liu; Guobin Li; Xianyong Yu; Pinggui Yi 📂 Article 📅 2011 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 95 KB

## Abstract A new class of spiro thiazolo[3,2‐__a__]pyrimidine compounds were synthesized by the one‐pot sequential 1,3‐dipolar cycloaddition of azomethine ylide (generated from isatin and sarcosine)–nitrile oxide to 2‐arylmethylidene‐6,7‐dihydro‐5__H__‐thiazolo[3,2‐__a__]pyrimidin‐3‐ones in modera