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Controlled trial of hydroxychloroquine and d-penicillamine singly and in combination in the treatment of rheumatoid arthritis

โœ Scribed by Thomas W. Bunch; J. Desmond O'Duffy; Richard B. Tompkins; W. Michael O'Fallon


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
807 KB
Volume
27
Category
Article
ISSN
0004-3591

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## Abstract Fiftyโ€seven patients took part in a controlled doubleโ€blind trial between tiopronin and Dโ€penicillamine as basic treatment for rheumatoid arthritis. Thirtyโ€nine (19 receiving tiopronin, 20 receiving Dโ€penicillamine) completed the trial after 1 year. Both drugs resulted in a decrease of

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## Abstract The medical records of our first 200 consecutive rheumatoid arthritis patients treated with penicillamine were analyzed retrospectively. All but 5 patients (97.5%) had undergone earlier chrysotherapy that resulted in either therapeutic failure or toxicity. Only 57 patients (28.5%) were