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Controlled multicenter trial of tiopronin and D-penicillamine for rheumatoid arthritis

✍ Scribed by Giampiero Pasero; Pietro Pellegrini; Umberto Ambanelli; Maria Laura Ciompi; Vincenzo Colamussi; Gianfranco Ferraccioli; Paola Barbieri; Maria Rosa Mazzoni; Germano Menegale; Donatella Trippi

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
692 KB
Volume
25
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

Fifty‐seven patients took part in a controlled double‐blind trial between tiopronin and D‐penicillamine as basic treatment for rheumatoid arthritis. Thirty‐nine (19 receiving tiopronin, 20 receiving D‐penicillamine) completed the trial after 1 year. Both drugs resulted in a decrease of the erythrocyte sedimentation rate, Ritchie index, and Lee index and in a sparing effect on symptomatic antiinflammatory therapy. Improvement in these variables was statistically highly significant at any interval with tiopronin, but was sometimes less or not at all significant with D‐penicillamine. Nevertheless, the difference in effects between the 2 drugs never reached statistical significance. Six patients receiving tiopronin and 6 receiving D‐penicillamine were taken out of the experiment because of side effects.

📜 SIMILAR VOLUMES

Clinical Trial of Penicillamine in Rheum
Clinical Trial of Penicillamine in Rheumatoid Arthritis
✍ Norman O. Rothermich; Marvin H. Thomas; Vol K. Phillips; Waldemar Bergen 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 532 KB

## Abstract The medical records of our first 200 consecutive rheumatoid arthritis patients treated with penicillamine were analyzed retrospectively. All but 5 patients (97.5%) had undergone earlier chrysotherapy that resulted in either therapeutic failure or toxicity. Only 57 patients (28.5%) were