Control of Hemoglobin Synthesis in Fetal Erythroid Cells by L-Thyroxine
โ Scribed by J. E. Fuhr; C. D. R. Dunn
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 303 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0361-8609
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DNA-synthesis state of circulating burst forming unit-erythroid (BFU-E) was evaluated in patients with sickle cell anemia and correlated with percent of fetal hemoglobin synthesized in the BFU-E-derived cells. Percentage of S-phase BFU-E inversely correlated with percent fetal hemoglobin synthesized
The biosynthesis of the minor hemoglobin F,c, which contains acetylated y chains, and the major hemoglobin F, was studied during erythroid cell differentiation and maturation in cultures of erythroid precursors isolated from five human umbilical cord blood samples. A gradual decrease in the synthesi