Relationship Between Cell-Cycle State of Erythroid Progenitors and Fetal Hemoglobin Synthesis

✍ Scribed by Keiichi Isoyama; Surendra Baliga; Arvind Shah; Vipul N. Mankad

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 181 KB
• Volume: 39
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830390115

✦ Synopsis

DNA-synthesis state of circulating burst forming unit-erythroid (BFU-E) was evaluated in patients with sickle cell anemia and correlated with percent of fetal hemoglobin synthesized in the BFU-E-derived cells. Percentage of S-phase BFU-E inversely correlated with percent fetal hemoglobin synthesized in the BFU-E-derived cells (simple linear correlation coefficient, r = -0.8, P = 0.0302; polynomial regression, R = -0.99, P = 0.0002). This observation is of relevance to our understanding of the relationship between the developmental stage of the erythroid progenitors and expression of globin genes.