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Contribution of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to hepatic uptake of nateglinide, and the prediction of drug–drug interactions via these transporters

✍ Scribed by Toshiyuki Takanohashi; Satoru Kubo; Harumi Arisaka; Kenji Shinkai; Kazuyuki Ubukata


Book ID
118111610
Publisher
Pharmaceutical Press
Year
2011
Tongue
English
Weight
414 KB
Volume
64
Category
Article
ISSN
2042-7158

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Organic anion–transporting polypeptide 1
✍ Iván L. Csanaky; Hong Lu; Youcai Zhang; Kenichiro Ogura; Supratim Choudhuri; Cur 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 713 KB

The organic anion-transporting polypeptide 1b family (Oatp1b2 in rodents and OATP1B1/1B3 in humans) is liver-specific and transports various chemicals into the liver. However, the role of the Oatp1b family in the hepatic uptake of bile acids (BAs) into the liver is unknown. Therefore, in Oatp1b2-nul