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Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

✍ Scribed by Anne T Nies, Mikko Niemi, Oliver Burk, Stefan Winter, Ulrich M Zanger…


Book ID
120705377
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
622 KB
Volume
5
Category
Article
ISSN
1756-994X

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Organic anion–transporting polypeptide 1
✍ Iván L. Csanaky; Hong Lu; Youcai Zhang; Kenichiro Ogura; Supratim Choudhuri; Cur 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 713 KB

The organic anion-transporting polypeptide 1b family (Oatp1b2 in rodents and OATP1B1/1B3 in humans) is liver-specific and transports various chemicals into the liver. However, the role of the Oatp1b family in the hepatic uptake of bile acids (BAs) into the liver is unknown. Therefore, in Oatp1b2-nul