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Contribution of D3 receptors to the in vivo binding of [11C]PHNO in the primate brain

✍ Scribed by Eugenii A. Rabiner; M. Slifstein; R.N. Gunn; C. Plisson; G. Gentile; X. Xu; M. Huiban; I. Bennacef; A.D. Gee; M. Laruelle

Book ID
118491206
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
60 KB
Volume
41
Category
Article
ISSN
1053-8119

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✍ Ariel Graff-Guerrero; Matthaeus Willeit; Nathalie Ginovart; David Mamo; Romina M πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 412 KB

## Abstract The D~2~ receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [^11^C]‐(+)‐PHNO is a PET D~2~ __agonist__ radioligand and therefore pro