๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Continual reassessment models in phase I clinical trials in cancer

โœ Scribed by John O'Quigley; Sylvie Chevret

Book ID
113297037
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
56 KB
Volume
11
Category
Article
ISSN
0197-2456

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Continual reassessment methods in phase
Continual reassessment methods in phase I trials of the combination of two drugs in oncology
โœ Andrew Kramar; Anne Lebecq; Emmanuel Candalh ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 153 KB ๐Ÿ‘ 2 views

Most phase I trials in oncology use standard methods for treating successive groups of patients with increasing doses in order to determine the maximum tolerated dose (MTD). These methods have been criticized because they treat many patients at suboptimal dose levels, and do not provide an accurate

Adaptive design improvements in the cont
Adaptive design improvements in the continual reassessment method for phase I studies
โœ Julie M. Heyd; Bradley P. Carlin ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 126 KB ๐Ÿ‘ 2 views

The continual reassessment method (CRM) enables full and e$cient use of all data and prior information available in a phase I study. However, despite a number of recent enhancements to the method, its acceptance in actual clinical practice has been hampered by several practical di$culties. In this p