Construction of 6-Amino-2,2-Dimethyl-3,4,6-Trisubstituted-2 H -1-Benzopyran Library by Solid Phase Synthesis
โ Scribed by Gong, Young-Dae; Seo, Jin-soo; Chon, Yong Sog; Hwang, Jong Yeon; Park, Ji Yeon; Yoo, Sung-eun
- Book ID
- 124080286
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 175 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1520-4766
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๐ SIMILAR VOLUMES
Highly enantioselective reduction of 3,4-dihydro-2,2-dimethyl-2H-l-benzopyran-4-ones 3 s-e by BH3 was achieved in the presence of catalytic amounts of Corey's oxazaborolidine 4 to afford the corresponding 3,4-dihydro-2,2dimetbyl-2H-l-~nzopyran-4-ols 2a-e in quantitative yields. These benzopyran-4-ol
The chiral intermediate diol (3S,4R)-trans-3,4-dihydro-3,4-dihydroxy-2,2dimethyl-2H-1-benzopyran-6-carbonitrile 2. was prepared for the total synthesis of a potassium channel opener drug candidate. The stereoselective acetylation of racemic lwas carded out with various lipases among which the lipase