Synthesis and antihypertensive activity of 6,7-disubstituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols
β Scribed by Evans, John M.; Fake, Charles S.; Hamilton, Thomas C.; Poyser, Robert H.; Showell, Graham A.
- Book ID
- 115463094
- Publisher
- American Chemical Society
- Year
- 1984
- Tongue
- English
- Weight
- 684 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
Highly enantioselective reduction of 3,4-dihydro-2,2-dimethyl-2H-l-benzopyran-4-ones 3 s-e by BH3 was achieved in the presence of catalytic amounts of Corey's oxazaborolidine 4 to afford the corresponding 3,4-dihydro-2,2dimetbyl-2H-l-~nzopyran-4-ols 2a-e in quantitative yields. These benzopyran-4-ol
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The chiral intermediate diol (3S,4R)-trans-3,4-dihydro-3,4-dihydroxy-2,2dimethyl-2H-1-benzopyran-6-carbonitrile 2. was prepared for the total synthesis of a potassium channel opener drug candidate. The stereoselective acetylation of racemic lwas carded out with various lipases among which the lipase