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Construction and characterization of a humanized single chain Fv antibody fragment against the main immunogenic region of the acetylcholine receptor

✍ Scribed by Danai Papanastasiou; Avgi Mamalaki; Elias Eliopoulos; Konstantinos Poulas; Christos Liolitsas; Socrates J Tzartos

Book ID
114138308
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
698 KB
Volume
94
Category
Article
ISSN
0165-5728

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✍ Jens Kleinjung; Marie-Christine Petit; Piotr Orlewski; Avgi Mamalaki; Socrates J πŸ“‚ Article πŸ“… 2000 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 351 KB πŸ‘ 2 views

## Binding of autoantibodies to the acetylcholine receptor (AChR) plays a major role in the autoimmune disease Myasthenia gravis (MG). In this paper, we propose a structure model of a putative immunocomplex that gives rise to the reduction of functional AChR molecules during the course of MG. The mo