Constitutive expression of c-fos gene inhibits type 1 collagen synthesis in transfected osteoblasts
β Scribed by Yasuo Kuroki; Shunichi Shiozawa; Toshitsugu Sugimoto; Takuo Fujita
- Book ID
- 115765670
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 416 KB
- Volume
- 182
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract To clarify the mechanism of the stimulatory effect of statins on bone formation, we have assessed the effect of simvastatin and atorvastatin on osteoblast activity by analysing cell proliferation, as well as collagen, osteocalcin, and bone morphogenetic proteinβ2 (__BMP2__) gene express
## Abstract Interaction between cβfos and 1,25(OH)~2~ vitamin D~3~ (VD) on the type I collagen synthesis was studied. VD inhibited collagen synthesis and type I collagen mRNA expression in MC3T3βE1 osteoblastic cells. In contrast, VD reversed the inhibition of collagen synthesis and mRNA expression