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Chronic alcohol intake inhibits retinoic acid synthesis and up-regulates AP-1 (c-Jun and c-Fos) gene expression in rats

✍ Scribed by Wang, X-D.; Liu, C.; Chung, J.; Stickel, F.; Seitz, H.K.; Russell, R.M.


Book ID
123464071
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
175 KB
Volume
114
Category
Article
ISSN
0016-5085

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Chronic alcohol intake reduces retinoic
✍ Xiang-Dong Wang; Chun Liu; Jayong Chung; Felix Stickel; Helmut K. Seitz; Robert πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 192 KB

Chronic ethanol intake may interfere with retinoid signal transduction by inhibiting retinoic acid synthesis and by enhancing activator protein-1 (AP-1) (c-Jun and c-Fos) expression, thereby contributing to malignant transformation. To determine the effect of ethanol on hepatic retinoid levels, reti