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Conjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs

โœ Scribed by Shinji Sakuma; Takaomi Matsumoto; Shinji Yamashita; Yanli Wang; Zheng-Rong Lu


Book ID
113691627
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
752 KB
Volume
123
Category
Article
ISSN
0168-3659

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IMPROVED ORAL ABSORPTION OF L-365 260, A
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L-365 260, a specific and potent nonpeptide antagonist of the CCK, receptor, is under investigation for its potential utility in the treatment of anxiety and panic disorders. This drug has a very low aqueous solubility (<2lgmL-'). When L-365 260 was given orally as a suspension in 0.5% methylcellulo