IMPROVED ORAL ABSORPTION OF L-365 260, A
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Jiunn H. Lin; David E. Storey; I-Wu Chen; Xin Xu
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Article
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1996
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John Wiley and Sons
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English
โ 706 KB
L-365 260, a specific and potent nonpeptide antagonist of the CCK, receptor, is under investigation for its potential utility in the treatment of anxiety and panic disorders. This drug has a very low aqueous solubility (<2lgmL-'). When L-365 260 was given orally as a suspension in 0.5% methylcellulo