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Conjugate Addition of Aryl Grignard Reagents to Unsaturated Azlactones in the Presence of Cuprous and Cobaltous Chlorides 1

✍ Scribed by Filler, Robert; Rao, Y. Shyamsunder


Book ID
126051790
Publisher
American Chemical Society
Year
1962
Tongue
English
Weight
366 KB
Volume
27
Category
Article
ISSN
0022-3263

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The synthesis of enantiomerically enriched a-amino acids is described, by means of the diastereoselective conjugate addition of Grignard reagent to (S)-2-acetamidoacrylic ethoxycarbonylphenyl-methyl ester 1 and its N-Boo derivative 5 in the presence of Lewis acids. The addition of magnesium organocu