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Regioselective 1,4-Conjugate Addition of Grignard Reagents to Nitrodienes in the Presence of Catalytic Amounts of Zn(II) Salts

โœ Scribed by Dhakal, Ramesh C.; Dieter, R. Karl


Book ID
123617383
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
303 KB
Volume
16
Category
Article
ISSN
1523-7060

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Asymmetric 1,4 addition of Grignard reag
โœ Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli; Claudia Tomasini ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 720 KB

The synthesis of enantiomerically enriched a-amino acids is described, by means of the diastereoselective conjugate addition of Grignard reagent to (S)-2-acetamidoacrylic ethoxycarbonylphenyl-methyl ester 1 and its N-Boo derivative 5 in the presence of Lewis acids. The addition of magnesium organocu