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ChemInform Abstract: Regio- and Diastereoselective Conjugate Addition of Grignard Reagents to Aryl Substituted α,β-Unsaturated Carbonyl Compounds Derived from Oppolzer′s Sultam.
✍ Scribed by Xiufang Cao; Fang Liu; Wenchang Lu; Gang Chen; Guang-Ao Yu; Sheng Hua Liu
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 46 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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Diastereoselective Addition of Allylic Reagents to Chiral α-Ketoimides Derived from Oppolzer's Sultam. -Additions of allylic reagents (II), (V), and (VI) to the chiral sultam derivatives (I) is described. High diastereoselection in these reactions is observed and in the case of the allyl-Tms (VI)/T
Catalytic Enantioselective Conjugate Addition of Grignard Reagents to Cyclic α,β-Unsaturated Carbonyl Compounds. -The outcome of the title reaction is influenced by many factors such as amount and structure of the chiral phosphine, copper salt, Grignard reagent, as well as the solvent used.