Congenital nonspherocytic hemolytic disease in Negroes associated with G-6-PD deficiency
✍ Scribed by A. Grossman; K. Ramanathan; P. Justice; N. Shahidi; D. Hsia
- Book ID
- 118534332
- Publisher
- Elsevier Science
- Year
- 1965
- Tongue
- English
- Weight
- 66 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1097-6833
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A new deficient variant of glucose-6-phosphate dehydrogenase (G6PD) causing severe congenital nonspherocytic hemolytic anemia (CNSHA) is described. The variant enzyme, characterized by slow electrophoretic mobility, extreme in vivo and in vitro lability, high Km for G6P and strongly acidic pH optimu
Three new glucose-6-phosphate dehydrogenase (G6PD) variants, which showed electrophoretically normal mobility and were associated with chronic nonspherocytic hemolytic anemia, were found in Japan. G6PD Ogikubo, found in a 17-year-old male whose red cells contained 3% of normal enzyme activity, had n