A new deficient variant of glucose-6-phosphate dehydrogenase (G6PD) causing severe congenital nonspherocytic hemolytic anemia (CNSHA) is described. The variant enzyme, characterized by slow electrophoretic mobility, extreme in vivo and in vitro lability, high Km for G6P and strongly acidic pH optimu
G6PD-Puerto Limón: A new deficient variant of glucose-6-phosphate dehydrogenase associated with congenital nonspherocytic hemolytic anemia
✍ Scribed by J. Elizondo; G. F. Sáenz; C. A. Páez; M. Ramón; M. García; A. Gutiérrez; M. Estrada
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 246 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0340-6717
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A new glucose-6-phosphate dehydrogenase (G6PD) variant associated with chronic nonspherocytic hemolytic anemia was found in a 20-year-old Japanese male who showed mild hemolysis after an upper respiratory tract infection. The patient had been noted to have jaundice and reticulocytosis several times
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