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Conformations of synthetic β peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells

✍ Scribed by Rene Buchet; Elizabeth Tavitian; Dorothee Ristig; Robert Swoboda; Urs Stauss; Hans Ulrich Gremlich; Laurence de La Fournière; Matthias Staufenbiel; Peter Frey; David A. Lowe


Book ID
116159965
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
659 KB
Volume
1315
Category
Article
ISSN
0925-4439

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The interaction between spironolactone (Sp) and hydroxypropyl-b-cyclodextrin (HPbCD) has been investigated in aqueous solution and in the solid state. Phase solubility studies indicate that the complex is formed with possible stoichiometry of 1:1 and association constant of 9806 M À1 . Differential