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Conformations and Interactions of BCL-2 Family Proteins: Implications For Apoptosis

✍ Scribed by Yao, Yong; Bobkov, Andrey A.; Plesniak, Leigh A.; Marassi, Francesca M.


Book ID
122781841
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
37 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract Bcl‐2 family members are the arbiters of mitochondrial apoptotic pathway, which is conserved through evolution. The stoichiometry of pro‐ versus antiapoptotic Bcl‐2 family members in the cell determines whether the cell lives or dies. This fine balance is regulated at the transcriptiona