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Conformationally restrained fentanyl analogs. 2. Synthesis and analgetic evaluation of perhydro-1,6-naphthyridin-2-ones

✍ Scribed by Borne, Ronald F.; Fifer, E. Kim; Waters, I. W.

Book ID
118004264
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
706 KB
Volume
27
Category
Article
ISSN
0022-2623

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✍ Robert L. Dow; Steven R. Schneider 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 29 KB

## Abstract The 5,6,7,8‐tetrahydro‐1,7‐naphthyridine (**7**) pharmacophore has the potential to serve as a confor‐mationally‐locked analog of the pharmacologically active 2‐(3‐pyridyl)ethylamine (**1**) core structure. This paper describes the synthesis of 5,6,7,8‐tetrahydro‐1,7‐naphthyridine (**7*