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Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1 H )-ones as Selective Inhibitors of pp60 c - src

✍ Scribed by Thompson, Andrew M.; Rewcastle, Gordon W.; Boushelle, Stacey L.; Hartl, Brian G.; Kraker, Alan J.; Lu, Gina H.; Batley, Brian L.; Panek, Robert L.; Showalter, H. D. Hollis; Denny, William A.


Book ID
119963318
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
255 KB
Volume
43
Category
Article
ISSN
0022-2623

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## Abstract A new series of 16 6‐chloro‐1,1‐dioxo‐7‐{4‐[(4‐R^1^‐phenyl)imino]‐4__H__‐3,1‐benzoxazin‐2‐yl}‐3‐(substituted amino)‐1,4,2‐benzodithiazines **7–22** was prepared in order to evaluate the cytotoxic activity against six human cancer cell lines. The structures of the new compounds were conf